Design, development and bioavailability study of prochlorperazine sustained release tablets

Dhandapani Nagasamy Venkatesh

Statement of the Problem: Prochlorperazine maleate is a well known anti-emetic drug used in the prevention and control of nausea associated with vomiting in the chemotherapy or radiation treatment of cancer. The usual dosage of the drug is three to four times a day due to its shorter half-life. At present there are no sustained release tablets available in India. Hence the purpose of our study was to investigate the in vitro and in vivo performance of the in house developed sustained release tablets of prochlorperazine prepared using hydrophilic polymer hydroxypropyl methylcellulose (HPMC) with commercially available marketed formulation.
Methodology & Theoretical Orientation: Sustained release tablets of prochlorperazine maleate were prepared by wet granulation method. All the composition with the exception of magnesium stearate and talc were deagglomerated using BSS sieve with 0.25 mm opening. The wet mass was passed manually through BSS with a 1.7 mm opening and the granules were dried at 60° C for 3-4 hours. The dried granules were passed through BSS with 1.0 mm opening. Then the lubricated blends were compressed using 8 mm concave punches at a 10 station rotary tablet press.