अमूर्त
Autoimmune disease and mitochondrial dysfunction in chronic diseases
Martins IJAnti-aging genes such as Klotho, FOXO 3a, p66shc and Sirtuin 1 (Sirt 1) are connected to various chronic diseases and repression of Sirt 1 is involved with the transcriptional dysregulation of other anti-aging genes (Klotho, p66shc, FOXO1/FOXO3a) that leads to abnormal regulation of glucose, lipid and amyloid beta metabolism associated with programmed cell death in various cell and tissues. Anti-aging genes and their connections to autoimmune disease and chronic diseases has attracted interest with relevance to irreversible programmed cell death in many tissues. Dietary effects with Sirt 1 downregulation accelerate disease progression with autonomous disease connected to a defective immune system in various global communities.
अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।