अमूर्त
Advances in targeted therapy for melanoma: a focus on MEK inhibition
April KS Salama & Kevin B KimIncreased knowledge of the role that dysregulated MAPK signaling plays in melanoma has opened the door for novel therapeutic strategies, among them MEK-targeted approaches. With the recent approval of the selective MEK inhibitor trametinib, both as a single agent and in combination with dabrafenib for patients with BRAF-mutant metastatic melanoma, MEK-based therapy now has a place as a standard of care option for the treatment of this disease. Early data suggest a benefit of MEK inhibition in other melanoma subtypes as well, including NRAS-mutant and uveal melanoma. This review summarizes the clinical development and the currently available data regarding the role of MEK inhibitor therapy in the treatment of advanced melanoma.
अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।